SAMe supports:

Joint Health
SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.

Brain Metabolism and Mood
SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes and precursor to acetylcholine, as well as neurotransmitters such as dopamine, norepinephrine, and serotonin, and has been shown to have a positive effect on mood.

Liver Functions
SAMe metabolism supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.